AREDS II Study Resolves Beta-Carotene Issues

By Teri Farley


Age-Related Eye Disease Study II, or AREDS II, is a study that looked at how nutrients affect eyesight. The initial study, completed in 2001, showed that high levels of antioxidants sometimes reduced the risk of developing blindness by 25 percent. There were some problems found after the study though and the subsequent study looked at those issues.

One very debilitating illnesses is that of blindness. In the United States there are nearly one million people that are blind. 90 percent of the blind are older. Eye disease can come about several ways. There are some people who are born blind. This can be as a result of problems in gestation or childbirth. Others go blind as a result of diabetes or they injure their eyes. Most blindness is caused by getting old.

There are some treatments available today, but most of them work only for a certain segment of affected people. Many people have used laser surgery and it has been found to be very effective. However, it is expensive and has side effects that could actually worsen sight. Side effects from laser surgery are not uncommon, although they are rarely severe. Still, they can cause you to lose your peripheral vision, can worsen your visual acuity, can reduce your night vision, or can even cause hemorrhaging.

AREDS, the initial Age-Related Eye Disease Study was finished and released in 2001. This study was begun to review risk factors and history associated with cataracts and AMD. Another purpose was to analyze whether higher doses of antioxidants might affect AMD or cataracts. They looked at a combination of vitamin C, vitamin E, zinc, and beta-carotene.

Researchers from the first study found that their formula could lessen the chance of blindness by 25%, in people who were considered to be in a high risk category. This category included people who had serious AMD in one eye already, or who had a milder form in both eyes. This only helped people with AMD risk and had no effect on whether someone would get cataracts. This was exciting news, however, later studies showed that the beta-carotene was linked to a cancer risk. People who smoked, and also took beta-carotene, had a higher incident of lung cancer.

The second study, completed in May 2013, had several interesting findings. One of their goals was to attempt to find a substitute for beta-carotene in the original formula. They found that the antioxidants lutein and zeaxanthin could be substituted for beta-carotene without reducing the effectiveness of this formula. People at high risk for developing advanced AMD should consider taking the antioxidant combination to reduce their chance of blindness.

A lot of the elderly are already on various prescriptions. In addition to this they may use over-the-counter drugs or supplements. The high-dose supplements in this combination could interfere or cause some of these medications to lose their effectiveness.

Laser surgery has some great effects but it is expensive and it can have serious complications. The initial formula discovered in the AREDS II may be a safer alternative to surgery. This study has confirmed that the formula of antioxidants and zinc reduce AMD risk. Furthermore, the study revealed that lutein and zeaxanthin were effective substitutes for beta-carotene. Before using any new medication please be sure to speak to your doctor.




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