Liposomal Encapsulation Delivers Medications More Efficiently

By Jody Leach


Drugs used to fight disease typically target specific physical systems or organs. Intravenous drips and injections are the most directly effective delivery method, transferring those medications directly to the blood. Orally administered drugs face degradation from the substances that accompany normal digestion. Liposomal encapsulation creates a protective bubble that wards off acids, while encouraging absorption.

Medical scientists first became aware of this process than fifty years ago, leading to the development of newer and more effective methods of drug delivery. The process is currently being used during treatment of serious conditions such as stubborn fungal infections, some kinds of cancers, and even age-related conditions leading to loss of vision. While standard medication delivery methods are still predominant, the encapsulation approach is also proving beneficial.

For drugs to survive the upper digestive tract intact, they need to be protected by some kind of barrier that does not cause any additional physical problems. The best solution so far is to create microscopic drug capsules using a material that is already a part of cellular walls throughout the human organism. When activated using one of three primary methods available today, tiny protective liposome bubbles are formed.

They are microscopic, and can easily pass through the stomach into the small intestine where the coating slowly dissolves, allowing the medication to be absorbed. In many cases, this process actually improves the therapeutic impact, and has the additional benefit of producing fewer side effects. Not all types of medicine are adaptable to this delivery system, which is primarily associated with water-soluble substances.

There are fewer unwanted physical reactions, and immediate advantages for patients. Because lipsomes are biodegradable and always physically compatible, they leave no toxic substances behind. Not only can they survive an attack by harsh digestive acids, but later function as tiny time-release agents within the intestine. Many drugs used to fight cancer can create collateral damage, and this form of delivery provides greater control.

While immediately useful in delivering medication, the process does have drawbacks. The cost of production remains high, but will very likely decrease as research into new product uses expands. There have been issues regarding seal leakage, and common oxidation may also reduce effectiveness. The half-lives of certain drugs decrease using this process, and long-term stability may be shortened. Even so, the potential benefits outweigh known negatives.

The past decade has seen a transition from strictly medical venue to include delivery of nutritional supplements and cosmetic materials. Anecdotal evidence of an increase in physical well-being associated with administering vitamins and minerals in this way are common. Vitamin C has long been touted as a natural way to combat the effects of upper respiratory infections, and this method is said to provide noticeably better results than pills alone.

Widespread information is available today regarding personal home encapsulation of vitamins, minerals, and herbal extracts. Producing high-quality encapsulated products is both costly and involved, and is not proven to effectively combat aging issues. As this effective method of physical drug delivery is improved and becomes more widespread, consumers will benefit most from its introduction to existing beneficial heal regimens.




About the Author: